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An annotation with a low P-value and a high estimated effect is considered as enriched for that trait, while an annotation negative estimated effects is considered depleted for that trait.
Because the logic underlying our model does not permit the mean daily blood lead increment to be negative, estimated values of mi were constrained to exceed zero using log transformation.
The negative estimated incidence values were the result of the postdischarge surveillance mandatory for the SSI-surveillance in the Dutch surveillance network.
The optimal number of factors was based on the bend in the scree-plot, a small root mean square residual (RMSR), no or a few negative estimated residual variances (ERVs), and an intelligible interpretation of the factors.
The problem is that the most negative estimated FEB does not necessarily correspond to the actual binding mode (here we call Best Pose) of the ligand found in experimental results [ 26].
These findings may provide a reasonable explanation for the more negative estimated percent changes in 5-min HRV indices after excluding observations in the top 5% and bottom 5% of the PM2.5 moving averages (Table 4).
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For GP5+/6+ PCR, number of false negatives estimated as 49 × 55/83 – 20 = 12.5, representing 23% of HMBS negative cases.
We used the restricted maximum-likelihood estimation technique to avoid negative estimates of variance.
However, our estimator is unbiased and therefore can produce slightly negative estimates of FST, which should not affect our calculations because the effect will not depend on ΔTE.
Thus, with the corrected data, we get a clear negative estimate for the actual data and no effect for the placebo sample – exactly what should happen if the negative estimated employment effect is not driven by a spurious correlation of minimum wage increases and negative shocks that are common across the border, but instead represents a real effect of the minimum wage.
Todd Slater, an analyst for Lazard, said his company was sticking by its negative estimates for Wal-Mart's store-against-store sales.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com