Obviously, the trash room and loud chute is a negative discovery, but everything else is nice".
In this sense, one of Cook's greatest legacies was negative discovery..
In this sense, one of Cook's greatest legacies was negative discovery.
Such a negative discovery might be conclusive enough for most legends to pass from rock-hard belief to literary artifacts of prescientific cultures living in a world of limited horizons and boundless mystery.
Furthermore, the study estimated a false negative discovery rate of ∼10%.
Second, each published yeast screen has its own, often unknown or unreported, false positive and negative discovery rates, which directly affects the likelihood of an overlap.
Beyond the consideration of the promoter input sequences and motif search spaces, improvements in the clusters provided to GEMS for analysis will likely also improve our false negative discovery rate in the future.
miRNA: microRNA; RISC: RNA induced silencing complex; E2F1: E2F transcription factor 1; MRE: miRNA recognition element; 3′: UTR: 3′ untranslated region; ceRNA: Competing endogenous RNA; LNA: Locked-nucleic acid; rmANOVA: Repeated measures analysis of variance; FPR: False positive discovery rate; FNR: False negative discovery rate; PCT: Probability of conserved targeting; ARE: AU-rich element.
Five (GmNAC011, GmNAC019, GmNAC 043, GmNAC092 and GmNAC109) and three (GmNAC041, GmNAC061 and GmNAC102) GmNAC genes previously reported as dehydration-responsive and dehydration-unresponsive, respectively, were also included in the qRT-PCR experiment as decoys to verify the positive and negative discovery rates (Supplementary Table S2).
Consequently, the false-positive and false-negative discovery rates are high, and limited reliable information is available regarding variation in gene expression profiles between healthy persons.
