Therefore, overexpression of the wild type TDP-43 could cause dominant-negative diminution of TDP-43 function in several different ways, e.g. driving oligomerization and aggregation, elevating the production of the C-terminal fragments and increasing the formation of non-functional complexes.
Some gains were lost at the 18 month follow-up, although improvement in general functioning was maintained and the experimental group showed improved negative symptoms (diminution or loss of normal functions, such as affective flattening, anhedonia, and attentional impairment) at 18 months.
"Positive symptoms" referred to an excess or distortion of normal functions (e.g., hallucinations and delusions) and the "negative symptoms" described a diminution or loss of normal functions.
Similarly D-cycloserine, a partial agonist at the glycine modulatory site of the NMDA receptor, has led to a diminution of negative symptomatology either alone or added to conventional antipsychotics [ 82, 83].
Thus, model cells exposed to both a decrease in [K+]e and a more negative glycocalyceal charge demonstrated a diminution of [Na+] and [K+] gradients and a depolarization of Em with respect to control cells, whereas neither of these maneuvers individually caused depolarization of Em.
Diminution of the negative EP, however, could be the consequence of degeneration of the organ of Corti that results from the lack of ILDR1.
Therefore, composites with PS can be more appropriate for the adsorption applications due to diminution of the mentioned negative effects [39 41].
Berlin termed this "negative liberty" and warned against its diminution; Breyer calls this "modern liberty".
Reelick et al [ 24] conducted a controlled before-after study of women participating in a cervical cancer-screening programme in the Netherlands and found that negative results were associated with a diminution in the scores for psychiatric disturbance at follow-up; hence screening offered a psychological benefit for some participants.
In this case, as shown above, the diminution (Delta t_{text{ss}}) is negative: Delta t_{text{ss}} = t_{2} left( {sigma_{1} } right) - tau_{2} left( {sigma_{2} } right) < 0. (12).
By reducing the probability of updating expectations in response to negative information, medication that enhances dopamine levels might lead to a diminution of a pessimistic outlook in depressed patients.
