Sentence examples for negative design of from inspiring English sources
Indeed, the negative design of the β-sheet edge supposedly helps natural β-sheet proteins to avoid β aggregation [36].
After five editions, the test-negative design of the cycEVA study has provided reliable information on annual influenza VE in Spain and may have important implications for the design of control influenza strategies.
This includes automated implementation of negative design by explicitly requiring higher free energy of the denatured state.
Although the detailed biologies of the two systems are very different, the unifying feature of both studies is the use of negative design principles.
The top-ranked designed complex exhibited an affinity of at least the wild-type level and a mode of binding that was remarkably specific despite the absence of negative design in the procedure.
Several methods accounting for negative design, through the use of explicit decoys [ 18] such as the use of a normalized energy gap between a native structure and misfolded structures [ 32], or using variational methods [ 19], also deserve further investigation.
The objective of this study was to use the test-negative design to determine the effectiveness of the 2010 2011 seasonal TIV against laboratory-confirmed influenza hospitalizations, a serious and highly specific outcome, among community-dwelling elderly adults.
Thus, glycine at 2g provides some of the negative design disfavoring interactions with off-target receptors, although at the cost of weakening binding to the Mcl-1 target (Table 2).
The test negative design comparing the vaccination status of the laboratory confirmed cases to that of patients testing negative for influenza was considered feasible and adequate for Spain, in the context of a pandemic [ 11].
The series design we consider is a test if negative design, based closely on the trial of Lehman et al. [ 5].
Like the single test design, the test if negative design can result in missed cases of disease but no false diagnoses.
