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All gap-filing solutions and the most feasible false negative correcting solutions were inspected manually, and for potentially realistic reactions, genes were predicted based on protein sequence homology.
After predicting sets of false negative correcting and gap-filling reactions, each of these sets of solution reactions was added to the iJO1366 model one at a time.
SMILEY was used to predict both gap-filling and false negative correcting reactions that could be added to the metabolic network.
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The picture is however quite different when paying attention to cantons presenting a negative corrected (or true) balance (B < 0) over the considered period.
Negative corrected spot intensities were set to +1.
Therefore, combinations of values yielding negative corrected cell frequencies are impossible and should be excluded from the sensitivity analysis.
Normexp adjusts the local median background, thus avoiding problems with estimates greater than foreground values, and ensures that there are no missing or negative corrected intensities.
DNA methylation level was positively correlated with the magnitude of the C allele (H C ) and negative corrected with the magnitude of the T allele (H T ) in MSD-SNuPET technique (Additional file 1: Figure S1).
Three items in test A and two items in test B with a negative corrected item-total correlation in both conditions (FS and NR) were eliminated from the dataset.
Positive correct responses were more accurate than negative correct responses.
Our results on CBCT images was between 79, 20%% to 89.10 % for positive correct and 75, 70 % to 95.30 % for negative correct for CBCT images.
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