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In healthy controls, compared with SAD patients, DLPFC exhibits significantly increased positive effective connectivity in afferents from the amygdala and increased negative connectivity in connections from the OFC.
Each coexpressed gene pair has either a positive connectivity or a negative connectivity based on the sign of the correlation coefficient that connects the two genes.
Further, ventral striatal connectivity with the posterior hippocampus and posterior insula demonstrated quadratic age-related changes characterized by negative connectivity in adolescence.
Genes with the highest changes after treatment with docetaxel were analyzed using CMap to identify drugs with negative connectivity scores, indicating these drugs had antagonistic effects on the genes associated with docetaxel resistance.
Using independent component analysis and functional connectivity analysis, we found that as compared with the sham feedback, the real feedback recruited stronger negative connectivity between the executive network (EN) and the posterior default mode network (pDMN).
A high negative connectivity score indicates that the corresponding perturbagen in the CMAP database may reverse the expression effects of the query agent.
Similar(35)
In this study, only the positive connectivity was demonstrated in the EM group, and both the positive and negative connectivities were confirmed in the CM and MOH + CM groups, which suggested that MrD demonstrated different pain modulation patterns in different subtypes of headache.
Based on empirical data showing a tendency for essential genes to form many relationships of both positive and negative connectivities, termed double connectivity [ 34, 39], we used Pareto optimization (see Methods) to identify essential genes as those that maximize the numbers of positive and negative coexpression relationships, simultaneously.
Gene-wise analysis shows that, regardless of letrozole treatment status, most genes have only a few coexpression partners and a propensity toward relationships of positive connectivity while a few genes have many coexpression partners usually incorporating both positive and negative connectivities.
Both positive and negative connections are connectivity in brain network.
In the top-down connection (OFC to amygdala), we found negative functional connectivity in HC (P < 0.01) and positive connectivity in SAD patients (P < 0.05) with a significant group difference (P < 0.05 corr).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com