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Exact(23)
This suggests that hypocretin needs to be cleaved, either extracellularly or in neurons that express hypocretin, to enable presentation of these peptides by antigen-presenting cells.
It seemed to be "violating the dogma" established with HIV and flu that the viral surface protein needs to be cleaved for the virus to enter the cell.
The HA0 protein of influenza viruses reportedly needs to be cleaved by host proteases to yield two subunits, HA1 and HA2 (Skehel and Wiley 2000; Stieneke-Grober et al. 1992).
For example, cell wall needs to be cleaved when applying RiMOS for fixed yeast cells (unpublished results).
Also, a bidentate substrate is likely to be more specific since it needs to be cleaved twice in order to produce an optimal signal.
Like ubiquitin, SUMO is produced as a precursor protein that needs to be cleaved to the mature form by one or more specific SUMO proteases (Ulps).
Similar(37)
The budded virion is still immature as the gag polyproteins still need to be cleaved into the actual matrix, capsid and nucleocapsid proteins.
For classical loading of HLA class I molecules, cytoplasmic antigens need to be cleaved into small peptides by the proteasome.
In contrast, PDGF-CC and –DD are secreted as inactive precursor molecules; N-terminal CUB-domains need to be cleaved off to activate the growth factors.
Both, HRSV F and HMPV F are structural proteins that are synthesized as inactive F0 precursors that need to be cleaved proteolytically before becoming membrane-fusion competent.
Before exported out of the nucleus by expertin-5, pri-miRNAs, which are capped and polyadenylated, need to be cleaved by Drosha to form hairpin-shaped stemloop structures of approximately 60 70 nucleotides (nt), namely precursor-miRNAs (pre-miRNAs).
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CEO of Professional Science Editing for Scientists @ prosciediting.com