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In order to be fully active, CPT-11 needs to be activated into the active compound SN-38 (7-ethyl-10-hydroxycamptothecin) by carboxylesterase (CE) enzymes (Tsuji et al, 1991; Satoh et al, 1994).
Of great importance for cellular regulation is the finding that Arp2/3 needs to be activated by Arp2/3 activating factors in order to function properly [ 100].
Not only could the mathematical model reproduce pore formation events at the experimentally measured amounts of mitochondrially accumulated Bax, it was also found that only a small fraction of the entire Bax pool (∼5%) needs to be activated in presence of activator and enabler BH3-only proteins to trigger pore formation.
It should be noted that, in the absence of IL-1, transfection with Egr-1 had no effect on PPARγ promoter activity, indicating that Egr-1 needs to be activated to achieve inhibition of PPARγ promoter activity.
Physiological active phenoloxidase needs to be activated by cleaving prophenoloxidase.
In order to display enzymatic activity, heparanase needs to be activated by cleavage, yielding a heterodimer of 8 and 50 kDa subunits [ 6].
Then it merely needs to be activated in the game's options menu.
A direct methanol fuel cell (DMFC) needs to be activated to achieve its maximum performance.
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To suppress T-cell responses, MSCs first need to be activated by cytokines produced by activated T cells [ 14, 15], like interferon-gamma (IFN-γ).
This is due to the lower amount of network resources that need to be activated to accommodate lower user activity during a weekend day.
As skinned fibres lack plasma membrane, they need to be activated by exposure to solution containing the activating ion, Ca2+.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com