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PPI is context-specific so it is important to tailor PPI to the emergent needs of trials and be creative to encourage active engagement.
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The limited resources available for clinical trials in developing countries mean that community stakeholders, researchers and sponsors will continue to face extremely difficult choices when attempting to reconcile the immediate needs of trial participants with the potential for longer term benefit to the wider community.
The International Criminal Court could help solve a central problem of dealing with the past -- that nations most in need of trials are least likely to be able to hold them.
Further measurements are needed of trials for drugs approved in other years, of additional sponsors (such as smaller companies and academic centres), and of the quality of reported information.
These centres tend not to be a pre-existing trial network, but are recruited on an ad-hoc basis for the needs of the trial.
There is a critical need for trials of combinations of existing registered drugs and new antimicrobial compounds, implementation of diagnostic testing combined with molecular detection of resistance, and antimicrobial surveillance.
Drug testing, too, would be simplified, as trial designers were able to select those more and less susceptible to the effect as the needs of the trial dictated.
Our informants identified a range of information needs of potential trial participants.
Think through plans for PPI and centre them round the aims and needs of the trial.
Regular meetings will be held according to the needs of the trial.
Equally, there is a risk of inadvertent PPI profligacy, that is, the encouragement of elaborate plans for PPI that are disproportionate to the needs of a trial.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com