They are, however, cumbersome, time-consuming and in need of optimization and standardization [13], thus it remains restricted to a limited number of specialized laboratories.
We suggest that this strategy of data mining is not only useful, but also indispensable, when the discovery of homologous sequences in a given dataset is in need of optimization.
This contrasts with the needs of lead optimization, in which one wants to find the smallest chemical change that makes the best similar compound.
Process design for CO2 Capture from power plant is becoming increasingly important in the past decades in view of the need for optimization of Capital Cost and Utility consumption.
Preconception care of diabetes (information about need for optimization of glycemic control before pregnancy, assessment of diabetes complications, review of dietary habits, intensification of capillary blood glucose self-monitoring and optimization of insulin therapy) versus none (3 studies: 910 participants) was associated with a reduction in perinatal mortality (RR=0.29, 95% CI 0.14 -0.14).
Four observational studies [ 29, 36, 71, 74] focused on the impact of preconception care (information about need for optimization of glycemic control before pregnancy, assessment of diabetes complications, review of dietary habits, intensification of capillary blood glucose self-monitoring and optimization of insulin therapy) versus no preconception care in pre gestational diabetes.
It is observed that most studies seek early detection of the infection and early antibiotic administration, which reinforces the need for optimization of processes for the bundle of the first hour of the sepsis protocol proposed by the Latin American Institute of Sepsis (ILAS).
The effect of culture medium on productivity of E. coli expression system has been studied by varying various media to achieve the optimal production of bioactive compounds [ 21, 22], indicating the need for optimization of culture conditions when attempting cultivation of new species.
The obvious need for optimization of the diagnostic process of SpA may have contributed to the positive perception that has developed regarding MRI as a tool in the SpA diagnosis.
Two studies (Temple et al.2006 [ 71] and Boulot et al. 2003 [ 29]) focused on providing intensive preconception care including information about need for optimization of glycemic control before pregnancy, assessment of diabetes complications, review of dietary habits, intensification of capillary blood glucose self-monitoring and optimization of insulin therapy.
