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However, every therapeutic challenge using the inhibitors for these pathways failed to cure diabetic complications including DN, indicating the inappropriate therapeutic strategy and needs for an alternative approach.
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"Early on, he recognized the need for an alternative to the volatility of the stock market".
And the intellectual need for an alternative set of institutions is itself far less apparent than it was.
"We came along at a moment where there was definitely an enormous need for an alternative place," Mr. Rogers said.
With interest rates sky-high, there was a need for an alternative, and the funds seemed to fill it.
"In the marketplace there will be an increasing need for an alternative given the shifts that have taken place recently," Mr. Sorrell said in the conference call.
The new hospital is the result of conversations beginning in 2003 among a group of city veterinarians about the need for an alternative to the Animal Medical Center.
He argued that there was a need for an alternative to the traditional groups who say, "to oppose any Israeli policy is to be anti-Israel".
When she returned to Nepal in 1999, she saw the need for an alternative space that could help contemporary art mature.
The PFA tries to educate players about the need for an alternative career and focus, but you can't wrap someone up in a zorb for when the day comes that their career is taken away.
In his much-quoted report, Eddington recommended three transport priorities to deal with familiar themes – a growing city, traffic gridlock and a need for an alternative to the West Gate Bridge.
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