The higher percentage of patients who need a dosage increase in some American studies might be explained by greater flexibility in the U.S. label or by a lower concomitant use of MTX in U.S. practice as compared with our study, in which 90% of the patients continue on infliximab + MTX combination therapy.
You can usually find toners, cleansers, and moisturizers in the store that contain glycolic acid, but if you need a stronger dosage, a dermatologist may offer a higher dose.
According to data released by the Linus Pauling Institute -- legacy of the late Nobelist, who advocated 18,000 milligrams of the stuff every day -- you now need a daily dosage of only 250 to 500 milligrams of C. It may not be long before the predictions in the Marshall Brickman-Woody Allen screenplay for "Sleeper" come to pass: that smoking, banana cream pie and bright red beef are good for you.
As a result, in order to achieve efficacious exposures, this younger group might need a higher dosage of daptomycin.
This may be one reason why rice seeds need a higher dosage for mutagenesis than Arabidopsis and sorghum.
Overall, patients with early (tREACH cohort) and established RA (FLARE cohort) had higher mean EC50 values in the IL-2 assay than did healthy controls (although not statistically significant in the FLARE cohort), indicating that RA patients needed a higher dosage of dexamethasone to suppress IL-2 mRNA expression in vitro.
Many plants would experience a decrease in fruit and flowering with a high-nitrogen fertilizer, but citrus trees are heavy nitrogen feeders and need a higher dosage than most plants for rapid growth.
Any further communication between the educator and the physician takes place only if the target weight needs to be re-evaluated, or if clarification is needed regarding a dosage change or other significant change that affected the patient's HF care through-out the course of the year.
Rational pharmacotherapy can be defined as prescribing the right medication to individual patients or populations, at the time when it is needed, using a dosage scheme that corresponds to the most suitable profile in terms of efficacy, side-effects and costs.
On the other hand, small animals needed a much higher dosage than humans, as was demonstrated by Mordenti and Chappell (1989).
