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The Battle of Quebec [token] represents the turning point [value] and this claim needs substantiation; historical turning points are in frequent debate.
Preliminary results in other indications need substantiation.
Accordingly, even a recent review concluded that "the working hypothesis that the BBB is a fluid generator, although attractive, needs substantiation" [ 4].
Despite needing more substantiation of such benefits in further trials we have been able to demonstrate that these users of NHS Direct did maintain or improve their overall quality of life.
Early on they say the reason Mr. Gotti was given suspended sentences in his youth was that "most local criminal court judges were known to have received their jobs from a political clubhouse system underwritten by Mafia money". The charge that the Mafia finances the city's political clubhouses is a strong accusation, one that needs some substantiation.
Favourable outcomes of SLT in patients with PACG, specifically in areas of non-occluded angle, need further substantiation through large controlled clinical trials.
The multiple interplay of components of the classical and alternative complement pathway in association with the activated immune system provide a possible mechanistic link between photoreceptor-degeneration induced upregulation of CD74 activation in microglia and secondary vasoregression, but the causal relationship between complement activation and vasoregression needs further substantiation.
This finding, though interesting, needs further substantiation in future studies.
Further study with larger sample sizes is needed for substantiation of the current result.
It has to be noted, however, that this argument needs further substantiation.
c) The reviewers feel that the dismissal of the published piwi data needs some substantiation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com