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In 23 patients (37%), Cmin was >5mg/L after the LD, notably in the presence of altered renal function at the onset of therapy, needing prolongation of drug administration.
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As patients requiring hemodialysis particularly have multiple comorbidities such as hypertension, angina pectoris, diabetes, hyperlipidemia, and cerebrovascular diseases with severe arteriosclerosis, these patients would need prolongation of CPB and extended ICU stay.
Candidaemic patients needed a prolongation of mechanical ventilatory support of 10 days [ 8].
Further investigation is needed into the prolongation of the cardiac QTc interval observed following piperaquine treatment [ 43].
Receiver operator characteristic (ROC) curves were used to illustrate the fluid volume needed to predict prolongation of the postoperative period of food intolerance to ≥ 5 days as well as the occurrence of any other complication (IBM SPSS Statistics Version 22).
The standard quantitative effectiveness formats are RRR - relative risk reduction ARR - absolute risk reduction NNT - number needed to treat POL – prolongation of life (or disease-/symptom-free survival) (Table 1).
It should also be remembered that thyroid function disorders can lead to QTc prolongation and, therefore, need correction [ 31].
Subjects were randomized to receive information in terms of absolute risk reduction (ARR), relative risk reduction (RRR), number needed to treat (NNT), or prolongation of life (POL) without heart attack, and were asked whether they would consent to treatment.
Friedman test, a non-parametric test comparing matched multiple groups, was used to test whether within subjects the responses (prolongation of pregnancy needed to change practice) differed significantly between the three interventions.
Since ethnic differences might be important for individual-specific risk of drug-induced QT prolongation, more research is needed to establish which drugs can be used safely in the different ethnic groups.
The hERG (IKr -testing paradIKr -testingnded in the paradigmsegulatorecommendedes (inH S7B, 2005) for predictheg drug-induced QT presentation may not adequately descregulatoryhe conditions needed to efficiently eliminate those compounds able to induce QT prolonguidelines hence TdP.
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