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More patients are needed to exclude a type II error.
In addition, some normative thresholds may be needed to exclude unsustainable (but possible) alternatives.
One could suggest that the large study populations would be needed to exclude the presence of statistically significant differences.
Further investigations may be needed to exclude the possibility of malignancy, and these require additional time and cost.
Investigations are needed to exclude other causes of burning as indicated in Figure 2. Figure 2 Causes of burning mouth.
Thus, smaller genotype-related effects cannot be excluded by our study, and larger multicenter studies would be needed to exclude such an effect.
A clinical neurological examination should be performed in all patients, supplemented by diagnostic tools if needed to exclude secondary headache [11].
Sometimes additional scanning of intracranial/cervical vasculature and/or the sellar/orbital/(para)nasal region are needed to exclude underlying pathological conditions [2].
However, medical practice changes with time, and laboratory investigation may be needed to exclude even very rare conditions in order to protect better patients and improve headache management.
There was a general consensus among our intensivists that three negative lower respiratory samples and low clinical pretest probability were needed to exclude MERS-CoV infection.
We just mention two results by recalling that, if enforced, this concept rules out bubbles in the complete market models described byJarrow et al. (2007); moreover, ND is precisely the ingredient needed to exclude bubbles in the setting ofHerdegen and Schweizer (2016), where fundamental values are modeled with superreplication prices.
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