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To generate a similar "maharishi effect" across the UK, however, Dr Clements said the Skelmersdale centre would have needed much larger groups.
In order to cope with the strong reduction of the muon flux due to the traversal of the volcano's edifice, a muon-detector active area of tens of square metres is needed, much larger than in previous investigations.
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You'd need much larger objects, and plenty of them, to bring substantial amounts of organic matter down from space, but 3.8 billion years ago there was so much debris flying around that astronomers call the period the Late Heavy Bombardment.
But lenders have tightened their standards since the slapdash days of the subprime boom; borrowers need much larger deposits than they used to.That is making it harder for young people to get on to the property ladder, cutting off demand at the bottom of the market.
Plans to restrict wind farms to seas around Britain will need much larger subsidies from consumers, experts say.
The system used was small in size, 0.5 m2 exposure area, and for practical domestic applications one would need much larger exposure area.
But he also cautions that, "All of these [new] technologies need much larger trials to prove their worth before they can be considered for routine use".
"We need much larger trials, on more diverse populations, before we can start to make a difference to how patients are treated".
However, we will need much larger sample sizes such that there are enough variants passing the significance threshold (Bonferroni or fdr) that are available for fitting.
Figure 3 shows the posterior densities of the ORs for the three rare SNPs that are suggestive of association but would need much larger sample sizes to reach statistical significance.
The additive effect can be generally well estimated, but the estimates of the dominant effects need much larger sample size.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com