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Further elucidation of associations among bone lead levels, bone turnover, micronutrient intake, and BLLs is needed in prospective studies.
More attention is needed in prospective clinical trials for elderly patients, further improving postoperative course and long-term survival.
If survival rates are to be used as an indicator of the quality of care in colic treatment, and if they are to permit hospitals, techniques and surgeons to be compared, the use of disease severity scores and a predefined set of reasons for euthanasia will be needed in prospective studies.
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Once a model is developed, validation is needed in a prospective trial.
However, to draw valuable conclusions, more research is needed in larger prospective studies with sufficient cases of stroke and CHD.
However, the actual role of GDF15 in tumourigenesis is still unclear, and further research regarding both its pathophysiological role and clinical use as a prognostic marker for CRC is needed preferably in prospective clinical trials.
FCSEMS with special antimigratory design may be superior and cost-effective compared with multiple plastic stents, but need evaluation in prospective and randomized trials.
This finding needs confirmation in prospective studies.
However, this finding needs confirmation in prospective comparative studies.
Targeted therapeutics as well as immunotherapies might be promising strategies, but need evaluation in prospective trials.
While significant progress has been made in this area, candidate biomarkers still need validation in prospective clinical studies [ 91].
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