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Rather, different products or products acting on multiple pathophysiological mechanisms may be needed for targeting the different pathophysiological mechanisms behind various symptoms.
For example, SNORD115, which is selectively expressed in the brain, is processed into shorter sequences lacking the stem sequence that is crucial for the assembly into a functional nRNP, but still containing the antisense box needed for targeting complementary RNA [ 129].
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Need for targeting vulnerable groups.
The level of contrast needed for target identification varies from 0.5% to almost 100%.
Furthermore, the ability to fully automate LRE analysis presents the prospect of developing high-throughput applications for absolute quantification that require few resources beyond those needed for target amplification [2].
Furthermore, the higher degree of contralateral preference in the easy search condition could be explained in the same way by numerous shifts needed for target detection in the difficult search condition.
More detailed analyses are needed for target validation of other KLKs and exploring the possible involvement of miRNAs in controlling kallikrein gene expression in ovarian cancer pathogenesis.
In the Hershberger bioassay, if the endogenous androgen is removed by castration, then an exogenous androgen source is needed for target tissues to grow and gain weight.
This suggests that profiling individual tumour types, using single cell sequencing techniques, to estimate intratumoural heterogeneity and molecular targets, may be needed for target-directed personalized therapies in the future.
However, the common definition of the TA-domain includes the TMD and the flanking aa concurrently needed for correct targeting [5].
The fluorescence imaging path is used to track cell and tissue movements and is needed for precise targeting of the ablating laser to specific cells or tissue regions.
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