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The level of contrast needed for target identification varies from 0.5% to almost 100%.
Furthermore, the higher degree of contralateral preference in the easy search condition could be explained in the same way by numerous shifts needed for target detection in the difficult search condition.
Furthermore, the ability to fully automate LRE analysis presents the prospect of developing high-throughput applications for absolute quantification that require few resources beyond those needed for target amplification [2].
More detailed analyses are needed for target validation of other KLKs and exploring the possible involvement of miRNAs in controlling kallikrein gene expression in ovarian cancer pathogenesis.
In the Hershberger bioassay, if the endogenous androgen is removed by castration, then an exogenous androgen source is needed for target tissues to grow and gain weight.
However, giving the laborious nature of the experiments needed for target validation, and considering that most ad-hoc developed high-throughput techniques (e.g. p-Silac) are costly and only validate a few target genes (Lim et al., 2005), it is imperative to improve in silico approaches to identify miRNA target genes.
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This suggests that profiling individual tumour types, using single cell sequencing techniques, to estimate intratumoural heterogeneity and molecular targets, may be needed for target-directed personalized therapies in the future.
Rather, different products or products acting on multiple pathophysiological mechanisms may be needed for targeting the different pathophysiological mechanisms behind various symptoms.
Need for targeting vulnerable groups.
Consequently, different scoring models (i.e., classifiers) are needed for each target.
Therefore, the number of pulses M i needed for each target can be calculated in Eq. (10).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com