Although we showed that serum cholesterol levels were reduced in Mbtps1 wrt/wrt mice, cholesterol does not seem to be the crucial metabolite needed for normal pigmentation, since a high cholesterol diet did not normalize the coat pigmentation of Mbtps1 wrt/wrt mice.
*Homocystinuria, occurring in one baby in 275,000, involves a deficiency of an enzyme that converts homocysteine into cystathionine, needed for normal brain development.
They revolutionized our understanding of how mammals learn to see, in particular of how early visual experience is critical for the development of special cells or mechanisms in the brain needed for normal vision.
The number of hungry people today could be as high as 1.5 billion (or more than 25% of the world's total), if the threshold was instead set as the minimum needed for "normal activity", or nearly 2.6 billion (nearly 45%) for "intense activity".
Thus, taking inhibitors commonly results in side effects caused by inhibiting other human enzymes needed for normal functioning.
Manganese is also a vital mineral, needed for normal growth; it helps breakdown fats, carbohydrates and proteins, and serves as co-factor for enzymes [5].
Now scientists know why: Two copies of a critical gene appear to be needed for normal growth, and Turner's survivors have only one.
Air entraining admixture dosages of up to 10 times the recommended dosage were necessary to obtain minimal air void properties similar to what is needed for normal portland cement concretes subjected to freezing conditions.
Since this ECM is very special in vocal folds, we anticipate that the co-culture with epithelial cells may also be necessary to stimulate VFFs towards production of the ECM needed for normal VF function.
Some physiological load is needed for normal bone growth, [[2]] but exceeding this physiological load can lead to unwanted morphological changes and different pathologies of the bone and joints [[3],[4]].
The filter beds were designed such that they do not remove Ca2+ and Mg2+ from the water samples because they are important ions needed for normal functioning of the human body.
