It featured very strongly during the hunt for the Higgs boson at CERN (usually in terms of "5 sigma" confidence being needed for a discovery, because that's how we particle physicists tend to do it), but is often absent in discussions which most people would see as being of much more immediate effect.
Multicomponent condensation strategies offer significant advantages over conventional linear-type synthesis in providing products with the diversity needed for the discovery of new lead compounds or lead optimization employing combinatorial chemistry[1, 2, 3, 4, 5, 6].
Thus, both tier 1 and 2 viruses are needed for vaccine discovery in nonhuman primate models.
In the post-genomic era, hybrid models that take advantage of different algorithms in different stages of gene selection are needed for biomarker discovery and disease classification.
Therefore, multiple libraries and additional EST sequences are needed for further discovery of significant MREs.
The amount of material needed has been considerably reduced (to ∼1 mg) as compared to the amounts previously needed for polymorph discovery with PIHn (∼300 mg).
Glycomics and glycoproteomics are needed for the discovery of new glycan biomarkers with better sensitivity and specificity for early detection of cancer, for evaluation of therapeutic efficacy of cancer treatment, and for assessment of prognosis.
The increased frequency of gene disruption detected, due to the consideration of multiple mechanisms of disruption, could potentially reduce the sample size of study cohort needed for gene discovery.
Designing biobanks and collaborating with other investigators in forming large data sets would enormously increase the generation of evidence needed for the discovery and validation of treatment selection markers.
Studies in Arabidopsis thaliana, a model species of the Brassicaceae family, have demonstrated the power of massively parallel transcriptome sequencing in providing high-quality representation of transcripts needed for gene discovery [ 17].
