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If needed, discontinuation or modification of the treatment may be considered at the discretion of the physician.
None of the adverse events were described as serious, or needed discontinuation of treatment and one of the studies reported no adverse events [ 40].
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However, when needed, treatment discontinuation and then the resumption of therapy are possible without loss of clinical efficacy in the long term.
This process requires guidelines and a firm grounding in not only what constitutes evidence or efficacy but, also as one interviewee held, "in order to look into effectiveness or efficacy, we need a discontinuation policy because we don't know the benefit [before the drug is tested]" (Australia Decision Maker 1).
None of the adverse reactions were severe enough to require discontinuation of therapy or to need hospitalization.
LD dAmB did not require any premedication, but none of the patients suffered from side effects, and nor was treatment discontinuation needed.
The precise level of endogenous creatinine clearance needed to allow discontinuation of renal support has not been established but is assumed to be between 15 and 20 mL/minute.
Further studies are needed to characterize medication discontinuation more carefully with consideration of time-varying factors.
Possibly, in patients with such extreme high values, a longer discontinuation is needed.
Therefore, patients will be advised to taper down slowly when discontinuation is needed.
The DSMB will advise the Scientific Committee on the continuation or, if needed the amendment or discontinuation of the trial.
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CEO of Professional Science Editing for Scientists @ prosciediting.com