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For example the following response, "When it snows and you aren't able to survive in the cold you need to mutate to survive" represents a misconception that mutations occur based on need.
"It would need to mutate.
Such behavior could emerge by convergent evolution and loss of the motif in the original site, as only a few amino acids need to mutate to make a new motif elsewhere in the sequence.
Furthermore, ABA-induced stomatal closing responses in these complementation lines confirmed the need to mutate both the S59 and S120 sites to alanine to significantly impair ABA-induced stomatal closing in planta.
mdm2 amplification is common in sarcomas, and most of these tumours retain wt p53 (Leach et al, 1993; Keleti et al, 1996), suggesting that tumours with Mdm2 overexpression bypass the need to mutate p53.
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That is because only large firms have been able to afford the supercomputers needed to mutate and crossbreed large virtual genomes and then simulate the behaviour of their offspring for perhaps 20m generations before the perfect design emerges.
That is because only large firms have been able to afford the supercomputers needed to mutate and crossbreed large virtual genomes and then simulate the behaviour of their offspring for perhaps 20m generations before the perfect design emerges.What has changed, in this as in so much else, is the availability and cheapness of computing power.
In order to add other unnatural amino acids into proteins by this approach, the amino acid binding site of M. jannaschii tyrosyl-tRNA synthetase need to be mutated.
This was not unexpected as we were unsure to what extent viral populations in vivo need to be mutated to achieve a hypothesized collapse, and whether this could have been achieved over the course of a 125-day study (subjects were treated for 124 days and the final sample taken for sequencing on day 125).
These studies reveal that both the S59 and S120 phosphorylation sites need to be mutated to disrupt ABA signaling in planta.
On average, roughly 10% or more of the nucleotides in each of several adjacent 50-mer probes would need to be mutated in order to approach our log2 ratio cutoff for deletions [ 45].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com