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If we want to check whether a PDE holds at a particular point, we need to known only the values of the function in an arbitrarily small neighborhood, so that all derivatives can be computed.
In addition, the modelers need to known how to process properly the prior information.
The following information is required to unequivocally demonstrate heterozygote advantage: (i) the gene and mutant alleles under selection must be known; (ii) the relative fitness of each genotype must be known (with heterozygotes exhibiting the greatest relative fitness); (iii) the mechanism of selection must be understood i.e. we need to known why heterozygotes are fitter than homozygotes.
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We need to know now".
You need to know that".
We need to know why".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com