All of these compounds are currently in use in the therapy of advanced CRC, but unfortunately none of them is potent enough to cure a substantial number of patients, thus clearly highlighting the urgent need for substantially improved therapies for this frequent cancer type.
The results of this study show that some methods need to be substantially improved upon, while others should be used routinely.
However, more than 65% of the protein-encoding sequences in the Leishmania genome cannot yet be assigned a function based on homology searches, and therefore it is likely that in silico models will need to be substantially improved as new metabolic pathways are identified.
Manganese oxides are the current favorite, but their native activity needs to be substantially improved before they can be considered as the substitute of noble metals.
An independent investigation (pdf) into the Crown Prosecution Service published this month has advised that trial advocacy for in-house advocates needs to be substantially improved at a time when more and more trials are being conducted by CPS lawyers, rather than members of the independent bar.
To reach its ultimate cost goals, Heliatek will need to substantially improve its panels' efficiency from 8percentto12percentcent.
The data suggest that all cattle farms need to substantially improve veterinary care, safety of milking, quality of milk and dairy products, ecological management, and sustainable grassland management.
Thus, there is a need to substantially improve food production in higher-risk environments and remote regions.
(6) The European Council, in its Conclusions of 2 December 2009, agreed that there was a need to substantially improve the mitigation of counterparty credit risk and that it was important to improve transparency, efficiency and integrity for derivative transactions.
Improving water, sanitation and hygiene facilities in schools is one of many steps needed to substantially improve students' performance.
35 37 38 More active implementation of the CONSORT statement and other reporting guidelines is needed to substantially improve the reporting of health related research.
