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When questionnaires are used, they are applied retrospectively, need interval recall, and are delivered on paper.
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The proposed iterative approach enables the selection of the needed interval constraints systematically, so that the tightest possible control is achieved without rendering the control problem infeasible.
Secondly, estimation of parameters in previous methods needs interval cases.
Patients with CrCl ≥50 ml/min less frequently needed interval adjustment (8/43 (19%)) than those with CrCl <50 ml/min (15/20 (75%), P <0.001).
Displacement activities such as watering my geraniums or answering emails, or remembering little songs and jokes to tell my grandchildren, give my brain much needed intervals of rest.
"We don't need an interval.
Plus the board kept saying: "We need an interval.
And you need an interval merely for that reason".
It's at gigs like these that you need an interval just to stop your ears ringing.
"You look far too young for a Fairport Convention gig," bassist Dave Pegg informs us before admitting "We need an interval now as some of us require the restroom".
We realised that if we did our job in creating a fit-for-purpose app, we wouldn't need any interval activities to "escape" to as the child would already be relaxed, engrossed in the performance and fully prepared for the 15-minute interval.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com