The findings in totality suggest a need for initiatives to improve the uptake of the KDIGO GN guidelines into clinical care.
Optimalists also think that general truths are true by default so there is no need for bespoke truth-makers for them (like totality facts).
In a similar way Armstrong endeavours to sweep away the need for negative facts by affirming "the biggest totality state of all, the one embracing all lower-order states of affairs", i.e., the existence of a totality state that consists in an aggregate of all the (1st order) states of affairs there are related by T to the property of being a (1st order) states of affairs (2004: 75).
The need for defining an explicit and relevant clinical question, exhaustively searching for the totality of evidence, meticulous and unbiased data transfer or extraction, assessment of between study heterogeneity and the use of appropriate statistical methods for estimating summary effect measures are essentially the same for the two approaches.
A recent Cochrane overview of systematic reviews [ 70] highlighted that such reviews provide an accessible summary on the totality of the evidence in the area and minimised the need for referral to individual reviews, however suggested that readers may wish to do so for specific details.
But the totality of her remarks -- coupled with her seeming skepticism of the need for a filter -- make it clear that she would find herself firmly on the periphery of the GOP tent should she end up in the Senate.
"The totality of animals, the crushing majority of men, live without ever finding the least need for justification," his narrator, a literature professor at the Sorbonne, reflects.
In totality natural water resources are also limited in Rajasthan so there is an urgent need for its proper planning, development and management of the available water duly taking care of environmental, ecological, socio-economic aspects and their inter-relationships.
Looking at this list now in its totality, I am struck by the fact that it is far less about my peculiarities and far more about the need for one of you (please, note, I am only asking for one) to study hard and get a good job and hire a driver, chef and housekeeper for me.
The "exposome" concept was first proposed by Wild (2005) to encompass the totality of human environmental (i.e., nongenetic) exposures from conception onward, complementing the genome; it was developed "to draw attention to the critical need for more complete environmental exposure data in epidemiological studies" (Wild 2012).
