Burnham said he had become convinced of the need for mandatory reformulation partly by the 10-minute rule bill presented by the former Labour minister, Keith Vaz, which sought to force soft drinks manufacturers to cut the frequently llarge amounts of sugar in their products.
Of course, every intellectually serious mode of Christianity has had to respond somehow to these challenges – this was the sense of Stephen Sykes' announcement that we are all liberals today; the particular character of liberal Christianity has been to find a response in accepting the force of the challenges and seeing a profound need for doctrinal reformulation to meet them.
Furthermore, as a result of the multiscale nature of the theory it can be specialized to single scale theories of the equivalent single layer (ESL) or discrete layer (DL) types in a unified fashion and without the need for any reformulation.
This proposed approach eliminates the need for the reformulation of the discrete /discontinuous optimization problems into direct MINLP problems, thus allowing for the solution of the original problem as a continuous optimization problem but only at each individual discrete and reduced search space.
One of the major inherent drawbacks of current influenza vaccines is the need for annual reformulation to antigenically match circulating strains.
Virus variants that are not recognized by previously elicited antibodies can render traditional vaccines that primarily elicit humoral responses ineffective, and therefore result in the need for vaccine strain reformulation and re-vaccination.
However, vaccine development faces a number of challenges, such as overcoming the limited effectiveness of a number of vaccines, the need for frequent vaccine reformulation, as well as a complete lack of vaccines for some diseases.
Although early studies discouraged the search for ED-specific maintaining factors highlighting instead the need of long-term treatments [ 77], some recent papers called into question the need for their identification and reformulation [ 70].
If suggestions for reformulation were made, they were analyzed individually by the researchers and reformulated on the basis of consensus.
