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Investment of labor in wet taro fields appears to have been a late prehistoric activity in most island groups, fueled by population increase and the need for intensification of production (Kirch 2010; Spriggs 2011).
This suggests a need for intensification of adjuvant treatment through the use of novel agents in cases with node metastasis.
The usual natural history is the progressive loss of insulin secretory capacity over time and the need for intensification of therapy.
Furthermore, the progressive deterioration of β-cell function, irrespective of pharmacological interventions to treat hyperglycemia, leads to an almost inevitable need for intensification of treatment [ 2].
Type 2 diabetes is a progressive disease and the usual natural history is of progressive loss of insulin secretory capacity over time and the need for intensification of therapy and polypharmacy [ 30].
Several factors may influence the need for intensification of treatment, including ineffective diet and exercise initiatives, limited pharmacologic armamentarium, conservative management, adverse events, poor compliance, underlying physiopathology, limited resources, and suboptimal healthcare systems (23).
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The effect of intensive agricultural systems on the environment is of increasing global concern, and recent review articles have highlighted the need for sustainable intensification of food production.
The need for process intensification reflects the fact that the conditions under which a biocatalyst carries out a reaction in nature are far from those which are optimal for industrial processes.
The B lymphocyte-rich spleen could be readily visualized by gamma camera scanning without significant background and without the need for image intensification or blood background subtraction techniques.
Due to dwindling arable land and ongoing unfavourable climatic changes, the need for sustainable intensification of agriculture has gained considerable urgency (The Royal Society 2009).
There is subsequently a need for sustainable intensification of livestock production in the sub-Saharan drylands (Havlik et al. 2014; Herrero et al. 2012).
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