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There is absolutely no need for gold chatons at this point — the technology has moved on — but Lange insists on using them.
This example emphasizes that in vitro evidence for synergy, while potentially informative, should not be the gold standard, underscoring the need for gold standards of synergy in the clinical context.
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Another tension was evident between what was considered the need for gold-standard evidence in the form of evaluation studies and the applicability of research from elsewhere.
That means, for example, that if a customer accrues more than the 25,000 miles needed for Silver status (but less than the 50,000 needed for Gold), they can apply the excess towards their status the following year.
Revenge famously came four years later when in a nail-biting finale he boldly forced Scheidt to the back of the fleet to prevent the Brazilian from securing the finishing place he needed for gold.
Sales of new material from former pop stars tend to be nowhere near the 500,000 unit sales needed for gold-record status, much less platinum sales of at least 1 million.
While a series of steps were proposed to avoid similar issues in the future [ 4], this case underscored the need for a gold standard and highlighted how such a gold standard might need to be redefined under the new light of biomarkers [ 4],[ 5].
During World War I, with gold coins commanding a premium above face value and many gold pieces returning from Europe to pay for war materials, there was little need for new gold coins; coinage of eagles was discontinued after 1916.
There is a need for the gold industry to address this issue and to meet the International Cyanide Management Code (ICMC) guidelines.
The advantages of using visual grading studies in the evaluation of clinical images are that these can be carried out with clinically available images and there is no need for a gold standard during the evaluation.
The development of a latent class model by Hui and Walter [16] to estimate sensitivity and specificity avoids the need for a "gold standard" which is rarely, if ever, genuinely perfect [17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com