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9, 10 However, since ∼30 40% of patients do not respond to initial pharmacologic SE treatments, 6, 7 there remains an unmet need for efficacious treatments that can augment LZP efficacy, preferably without the risk of respiratory compromise.
In spite of the need for efficacious, convenient and safe treatment for mucus hypersecretion, current choices are few with limited data to support their efficacy in COPD [3],[4].
These findings stress the pressing need for efficacious, systemic chemotherapy for patients with inoperable HCC.
Given the degree of reported impairment in their HRQOL, the urgent need for efficacious treatments is quite evident.
Despite advances in therapeutics, outcomes for hepatocellular carcinoma (HCC) remain poor and there is an urgent need for efficacious systemic therapy.
The recent Ebola virus (EBOV) epidemic highlights the need for efficacious virucidal products to help prevent infection and limit the spread of Ebola virus disease.
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The pharmacotherapy of stroke includes few agents with proven efficacy [ 10] underscoring the need for novel efficacious treatments.
This highly aggressive phenotype mandates the need for more efficacious therapies.
Accordingly, there is an urgent need for new efficacious anti-malarial drugs.
Although docetaxel offers improved survival for this patient population, it is also associated with toxicity and resistance in many patients, representing a need for more efficacious therapies.
Recent animal genetic models point to the potential validity of several neuropeptide receptors as targets for drug discovery, though the need for safe, efficacious compounds cannot be underestimated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com