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Intratumoral heterogeneity poses challenges for cancer treatment, motivating the need for combination therapies.
This finding emphasizes the need for combination antiretroviral prophylaxis to prevent mother-to-child HIV transmission.
These melanomas are resistant to BRAF inhibitors highlighting the need for combination therapy [27].
This underscores the need for combination therapies to reduce the chance of clinical failure.
ACPA status influences the need for combination DMARDs and high-dose tapering corticosteroids in early RA.
ACPA status influenced the need for combination treatments to reduce radiological progression.
Similar(35)
Like Tyga's "Rack City," another of his freelance gigs, it's immediately identifiable: booming and square, like well-sequenced jabs with no need for combinations.
Such complex interactions could underlie the need for combinations of immunostimulants to produce the strong antitumor effects observed in these experiments.
31 The limited long-term efficacy of these therapies underscores the significant need for new medications with novel mechanisms of action, as well as the need for combinations of agents targeting the multiple pathologies underlying T2DM.
A recurring theme of the meeting was the need for combinations of techniques to understand ABC transporter function/mis-function and role in physiology/disease, particularly for rare disorders and diseases with complex aetiologies.
Exhaustive search requires an exponential computational time in the number of nodes and projecting from the time needed for combinations of 1,2,3 nodes, that is respectively 1 minute, 1.5 hours and 7.5 hours, we estimate that around 90 days would be needed to study all the combinations of 4 drugs.
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