Conclusion: This study showed that mitomycin C was efficient in inhibiting GM-CSF synthesis with reduction of IL-5 secretion, but this fact needs complementary studies.
Determining the taxonomic status of the clusters identified here is beyond the scope of the present study, and would need complementary data such as nuclear markers and morphological data.
Nevertheless, the results obtained at the 25 and 50 mg/kg dosages of the evaluated carbamates suggest caution and the need for complementary studies that evaluate the in vivo and in vitro cytotoxic and genotoxic potentials and the environmental repercussions of the carbamates LQM 919 and LQM 996.
Obviously, QSAR community needs complementary data sharing and distribution mechanisms.
The difference in results between these two studies demonstrates the potential influence of investigators' methods in observational cohort studies and emphasizes a need for replicative and complementary studies in scientific inquiry.
However, complementary studies are needed to identify the best levels of brown propolis to add to these diets.
Based on these reports, complementary studies are needed to determine whether the beneficial effects of SC are applicable to the treatment of neuroinflammatory and neurodegenerative diseases.
Complementary studies are probably needed to determine this latter aspect.
However, whether the described phenotype observed in Ins2-Cre mice reproduces the pathological mechanism that occurs in individuals with FRDA needs to be further investigated through complementary studies in the mouse model and in patients.
Therefore, complementary studies in preclinical models of CF lung disease are needed to define the relative roles of these disease-promoting versus protective functions of NE and potentially other proteases in the in vivo pathogenesis of CF lung disease.
