Neck orientation can also be changed after implantation, which as is well known can be the cause of early dislocation.
Some facial characteristics such as the inter-pupillary angle and the head on neck orientation [ 61] were quantitatively evaluated using digital photographic material.
The neck linker orientation might be determined using label such as Skiniotis et al. (Skiniotis et al, The EMBO Journal Vol. 22 No. 7 pp. 1518-1528, 2003).
In addition to inter-head tension, we found that neck-linker orientation is also responsible for ensuring gating in kinesin.
In particular, the predicted necking band orientation when the bilayer is under in-plane loading with a negative ratio (e.g., uniaxial tension) agrees with the slanted necking bands observed in experiments, a phenomenon that cannot be explained by existing theoretical studies assuming plane strain condition.
3) Overall motor domain conformations (including neck-linker orientation) are consistent with nucleotide assignment as expected from the literature.
Cement type (viscosity); maximum, minimum, or mean cement mantle thickness; cementing grade; degenerative or inflammatory disease; stem size; neck size; or orientation had no (statistically significant) influence on migration (pattern) of the stem (all p > 0.01).
Andreasson, Milic et al. thus propose that, at the unbinding gate, it is not the tension between the heads that coordinates the mechanochemistry of the heads: rather, it is the spatial orientation of the neck linkers (in particular, the spatial orientation of the neck linker belonging to the front head) that is responsible for coordination.
We then show that the ATPase site and the switch I and II regions are unperturbed while the neck linker region changes orientation around Lys258, with His257 interacting with the C-terminus.
The location of the bud neck and the mother daughter orientation were determined using the first tdTomato-labeled cell membrane exposure.
