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Because of the necessity to decrease such burden, surveillance is the primary public health strategy to emphasize, but a set of questions arise spontaneously.
In view of the absolute necessity to decrease pulmonary vascular resistance, it was decided to perform balloon angioplasty (BA) and stent implantation in the pulmonary arteries.
This follows the general trend within mammals that there are more specialized sensory areas with increasing size of neocortex, perhaps because of the necessity to decrease the length of connections between similar inputs [ 25].
The necessity to decrease cytosolic Ca2+ concentrations to submicromolar levels by exporting the cation into extracellular spaces or intracellular compartments that do not generate ATP, such as the endoplasmic reticulum or vacuole, creates a steep concentration gradient that allows for the controlled and gated generation of rapid Ca2+ transients in response to extracellular stimuli.
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This is associated with a mortality rate approaching 50% in the case of septic shock [ 3, 4], despite the development of novel treatments such as early appropriate antibiotherapy, early goal-directed therapy, and activated protein C. Therefore, a better understanding of pathophysiology of severe sepsis is a necessity if we are to decrease the high mortality rate of this condition.
Additionally we explored ways to decrease the necessity for Tc in order to "silence" the system.
Broadcasting and recording widened even further the potential audience for concert artists, at the same time as they tended to decrease the physical necessity for large new public performance arenas.
There is also a necessity to homogenize the management of these patients to decrease the risk of death.
This shows the necessity of using a suitable drug delivery system to decrease the drug toxicity by locally delivering the drug to the site of action.
The primary end-point variable was to decrease reintubation rates, defined by the necessity of mechanical positive-pressure ventilation through orotracheal intubation in the first 48 hours after extubation, in the treatment group.
Small RNA deep-sequencing analysis is often restricted by the necessity of bioinformatics analyses flexible enough to explore every aspect of the miRNome and to decrease technical biases [ 22, 29].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com