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The results obtained from the necessity study (MEK siRNA) and sufficiency study (LeTx and MEKcr) are not actually contradictory as the two experimental systems model fundamentally different cellular contexts.
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This study is limited in that we have, by necessity, studied cases with more severe epilepsy, which will not represent the broader epilepsy population.
Conflicting results in previous studies underline the necessity to study HG's potential effect on pregnancy outcomes using large cohorts with valid data on exposure and outcome measures, as well as potential confounders.
The fact that a considerable number of authors of these studies already seem to endorse the necessity of study registration is promising.
Field investigation is a necessity to study land subsidence consequences and damages.
Recent studies confirmed the necessity of studying multiple distinctionic ion channels which are responsible for cardiac related diseases or TdP, to obtain an improved clinical TdP risk prediction of compound interactions and also for designing drugs.
Therefore, there is necessity to study thoroughly the issues of the optimization of discrete optimal problems.
So there is great necessity of study for IWCT service network design.
The presence of carbonate deposits at many strategic petrochemical reserves implies the necessity to study the behaviour of these soils.
Relevance of the paper is due to theoretical and practical necessity to study the peculiarities of design education.
The unpredictable consequences of earthquakes have proven the necessity to study the shear mechanism of low-rise reinforced concrete walls further.
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