This will be, at least partially, mitigated by careful explanation of the necessity of taking trial medication upon entrance into the trial, and performing pill-counts at the end of the study.
(Presumably relevant as well is the importance of discretion when letting an employee go, detailed on pages 129-130: termserms of Welch's divorce from Jane were reached privately, before the necessity of a trial).
An analysis of network database may provide the necessity of clinical trial or standardisation.
This device addresses the stability required for interbody fusion, and supports the necessity of clinical trials using this alternative to the circumferential fixations.
The reanalysis of Study 329 illustrates the necessity of making primary trial data and protocols available to increase the rigour of the evidence base.
A high cost is involved in this case due to the necessity of another film, trial procedure and professional staff time.
This simple-to-use correlation can be of immense practical value for petroleum engineers to have a quick check on estimating the critical oil rate for wide range of conditions without the necessity of any field test trials.
The proposed simple-to-use approach can be of immense practical value for petroleum engineers to have a quick check on estimating the simultaneous water and gas breakthrough time and the optimum location of horizontal well in the presence of both gas cap and aquifer for wide range of conditions without the necessity of any field test trials.
Doubt has arisen on the role and necessity of animal feeding trials in safety and nutritional assessments of GM plants and derived food and feed [1].
Despite these efforts, the global prognosis still remains much inferior to those of B-cell lymphomas, highlighting the necessity of multicenter clinical trials.
