It is legitimate to accuse China, India and others of being deliberately obstructive to show off their political muscle, even while they acknowledge the necessity of reductions in carbon emissions.
Recently published studies further challenge the necessity of open reduction of a displaced fracture, advocating good results following close reduction and internal fixation (CRIF) of completely displaced and rotated fragments [9].
While "there are some Democrats who simply don't believe in the necessity of deficit reduction," one administration official said, "most do.
"Analysis of the data concludes that the necessity of deficit reduction on the scale undertaken by the coalition is debatable; yet it is certainly the case the austerity agenda could have taken an alternative form – such as additional tax rises targeted on more affluent sections of society – in order to mitigate its impact on the most deprived groups.
25 For nonambulatory patients, the necessity of fracture reduction depends on the type of fracture, the level of contractures, and preserved mobility.
Patients who had a long-lasting relationship with their GP appreciated when he or she was forthright about the necessity of weight reduction.
In addition, removing globin-specific oligos from the DASL Assay Oligo Pool (DAP) should decrease noise associated with the high abundance of globin mRNA transcripts and potentially eliminate the necessity of globin reduction.
An earlier, larger trial had similar results, but was statistically significant only for the first cycle and did not correlate with necessity of dose reduction (Toffoli et al, 2006).
As observed here and found in many other ensemble studies, the dominating error source turns out to be the bias and irreducible error (Bauer and Kohavi 1999), which suggests necessity of bias reduction in ensemble learning.
In conclusion, our study confirmed that the combination of docetaxel and epirubicin is highly active in MBC and has a favourable toxicity profile when administered in a weekly schedule, which allowed administration of the full-programmed dosages without the necessity of dosage reduction due to side effects.
