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To be considered eligible, patients had to satisfy the following inclusion criteria: age from 18 to 40 years, diagnosis of Schizophrenia or Schizophreniform disorder according to the DSM-IV criteria [ 29], illness duration of 10 years or less before study entry, necessity of long term antipsychotic treatment.
It is difficult to draw strong conclusions on the necessity of long term follow-up for babies with low arterial cord pH, as the observed association with cerebral palsy was in a limited number of primary studies and the association, although statistically significant, was only moderately strong and based on studies of varying quality.
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Furthermore, the comparison has also been carried out from the costs point of view, to verify the necessity of long-term subsidizing policies.
Obtaining field data for coevolutionary dynamics presents practical difficulties, such as the necessity of long-term surveys.
CBC occurrence adversely affects prognosis, emphasizing the necessity of long-term surveillance directed at early CBC-detection.
28 Of note, treatment responders were more frequently administered daily oral corticosteroids and/or immunosuppressants compared with nonresponders, suggesting the necessity of long-term immunosuppression for sustained improvement.
Due to the chronicity of the disease and the necessity of long-term pharmacological intervention, long-term studies are important to establish continued efficacy and safety.
Because of the side effects and the necessity of long-term daily use of this drug, patients can have difficulties in complying with the treatment.
Furthermore, it might enable the evaluation of therapeutic agents concerning their anti-inflammatory potential and the necessity of long-term (in vivo) experiments.
The necessity of long-term exposure for effective growth inhibition and the considerable margin between cytostatic and acute cytotoxic indolocarbazole concentrations are findings which might influence the planning and interpretation of clinical trials of these kinase inhibitors.
The work by Bonapace and colleagues has highlighted the necessity of long-term studies, raising important considerations regarding the use of clinical interventions which transiently interfere with the tumour microenvironment (and thus transiently show pleasing therapeutic outcomes).
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CEO of Professional Science Editing for Scientists @ prosciediting.com