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However, the necessity for administration by injection, their high production costs and the risk for allergic reactions or the generation of an adverse immune response are drawbacks of the antibody approach, although the latter can be prevented by humanization procedures.
Ongoing investigations of abiraterone are evaluating its efficacy in earlier disease states, exploring its synergy in combination with other therapeutic agents, and assessing the necessity for administration of concurrent steroids and gonadal suppression.
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Kerlikowske selected a particularly innocuous segment of Obama's response, in which the president describes the necessity for his administration to "reconcile a federal law that still says marijuana is a federal offense and state laws that say that it's legal".
This raises the possibility of generating ApoE preparations for therapeutic use without the necessity for MSC administration.
Inadequate glycaemic control by OAD treatments including multiple agents would indicate a necessity for insulin administration, often in the form of BOT [ 8].
Native GLP-1 is not used as a glucose-lowering agent in ambulant type 2 diabetic patients because of the necessity for continuous administration [ 4].
Recurrent infections are of particular concern because of the repeated morbidity and necessity for frequent administration of antibiotics with the possible adverse consequences of selection of antimicrobial-resistant strains.
Although many studies reported recovery of cognitive function(s) after glioma surgery to the preoperative level, the more extensive neuropsychological protocols still found deterioration in some cognitive domains in a follow-up, indicating the necessity for the administration of several tasks in different cognitive domains.
Intraoperative MRI is also limited by the necessity for frequent administrations of gadolinium (Gd -chelates because of their short blood half-lives, and by the inaccuracies of false-positive contrast enhancement.
An important aspect was the necessity for analgesic drug administration.
Its application could reduce the necessity for repeated drug administration at frequent intervals due to the sustained release of the formulation, thereby potentially lowering corneal toxicity and increasing patient compliance.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com