Sentence examples for necessity a dose from inspiring English sources
While Knowles is careful not to imply that Fern's, or her family's, troubles are over, she nevertheless allows the children a sparkling, madcap evening of fun that seems more a narrative necessity (a dose of hope!) than a plausible eventuality.
This involved the correlation of tumour F signal with plasma SR4554 levels and of the necessity achieving a dose of SR4554 capable of producing a F signal of sufficient intensity to be reliably detected by localised MRS. Variable success at the dose defined by the initial safety study led to a limited further dose escalation of SR4554 made possible by administration of a prophylactic antiemetic.
In general creatinine-based equations resulted in a lower eGFR-estimation and in a higher necessity of drug dose adjustment than Cystatin C-based equations.
An earlier, larger trial had similar results, but was statistically significant only for the first cycle and did not correlate with necessity of dose reduction (Toffoli et al, 2006).
Since methylnaltrexone is likely to be used in multimorbid patients, its interaction with other drugs and the necessity of dose adjustment in patients with renal insufficiency or failure also need to be determined.
The necessity of dose adjustment for special populations is suggested by Fig. 2; for example, 200 mg of garenoxacin given to a patient with low body weight (<40 kg) or moderate to severe renal impairment might be enough for adequate efficacy.
Owing to the necessity to deliver dose in a precise manner, the use of proton therapy is becoming the treatment of choice for these tumours.
The first is the necessity for a loading dose at the beginning (the first day or two) of a treatment regimen and the considerably lower dose requirement thereafter to sustain suppression.
It is of necessity a collective thing.
