In our hands, and anecdotally in the hands of others, they tend to be highly variable, necessitating time-consuming optimization of conditions.
The most evaluated hypoxia tracer is 18F-fluoromisonidazole ([18F]FMISO) [12], which shows slow clearance from normoxic tissue, likely due to its lipophilicity, necessitating long time intervals between injection of the tracer and imaging.
"For whatever reason, the Burbank Unified School District has decided … to retain Ms. Doumanian's law firm, and the litigation has been replete with rule violations necessitating extra time and work on the plaintiff's side, and certainly on the court's," Murphy stated in 2014.
The nature of the hospice inpatient population, with most patients in the terminal stage of their illness, limits the number of patients well enough to participate, potentially necessitating lengthy time-scales for sufficient data collection.
The channels in this area are upward of 40 feet deep, but they constantly grow more shallow over time, necessitating dredging.
It is often the case that the operational environment of the system changes over time, necessitating evolution of the architecture.
This has to do with factors such as there is no online central authority, many nodes are limited in their computational resources, nodes may go offline at any time necessitating redundancy, and nodes are not guaranteed to be completely trustworthy [21].
Aims: Most treatments for type 2 diabetes fail over time, necessitating combination therapy.
However, objective measures generally collect data over brief periods of time necessitating serial measurements for the ascertainment of habitual patterns of behavior.
