Carboxyfluorescein diacetate succinimidyl ester-based approaches provide a highly sensitive method for detecting T cell responses, particularly when used together with other activation markers, such as CD25, but bystander proliferation can decrease specificity [ 38] necessitating validation of potential T cell epitopes in large patient cohorts.
AS systems, when used as a method to identify new safety signals, often derive multiple potential links, necessitating development of algorithms that are informed by and integrated with clinical and scientific assessment to further prove causality; the SRS and other sources may be used to prespecify potential AEs of interest [ 15].
**Percent of confirmed cases with positive association noted for respective exposures This study demonstrates that we can successfully identify adult-onset asthma in HMO data with high sensitivity and specificity, but that the high sensitivity is gained at the expense of a relatively low predictive value positive – necessitating manual chart review of potential cases.
The structural integrity of dies of this type is paramount as the thermally sprayed layer has the potential to de-bond necessitating repair or retirement of the dies.
Mass spectrometry (MS)–based proteomics is a powerful technology, allowing for the identification and quantification of hundreds of proteins in parallel from a single sample without necessitating prior selection or exclusion of potential analytical targets.
However, these studies have typically relied on routinely collected data, limiting the pool of potential predictors available for study and necessitating crude variable measurement.
In twin deficit countries, the private sector's financial surplus is not big enough to cover the government deficit fully, necessitating foreign borrowing by the sovereign with all sorts of potential ramifications.
This is because poor adherence gives rise to the potential for development of drug-resistant strains [ 3], necessitating administration of expensive second-line therapy, and the possibility of transmission of drug-resistant HIV by non-adherent patients [ 4, 5].
To summarize, disruption of the membrane potential at low extracellular pH attenuates membrane potential-driven uptake of K+, necessitating induction of the genes encoding the active K+-uptake systems to enable survival.
While cutaneous delivery has great potential, the closest method used currently in the clinic – intradermal injection – is technically difficult, necessitating development of advanced targeting methods as reviewed in [8], [9].
