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Lithium has adverse effects on the kidneys, thyroid gland and parathyroid glands, necessitating monitoring of these organ functions through periodic blood tests.
With the proximity of the aortic valve annulus to the conduction system there is, however, an unknown risk of conduction disturbances necessitating monitoring and often cardiac pacing.
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These results demonstrate that chemicals added during wastewater reclamation can foul downstream membranes necessitating careful monitoring of existing wastewater treatment unit operations and RO pretreatment processes.
Worldwide blooms of toxic cyanobacteria (blue-green algae) commonly occur in freshwater, often in drinking water sources, necessitating routine monitoring of water quality.
However, patient-specific factors were poorly predictive of the temperature or cooling time required to achieve ECI, necessitating EEG monitoring for precise ECI detection.
Diaz et al [ 31] stressed that the response to HBV vaccine may be transitory in AIDS necessitating progressive monitoring of HbsAbs.
Methadone can increase levels of zidovudine by up to 43%, necessitating close monitoring of zidovudine-related adverse effects (ie, anemia, bone marrow suppression).
GH secretion is not inhibited during pegvisomant therapy and pegvisomant does not treat the tumor, necessitating regular monitoring for pituitary tumor growth [ 116- 118].
Quinine may also cause hypoglycaemia and prolongation of the QTc interval on an electroencephalography (ECG) necessitating regular monitoring, but is usually well tolerated.
But difficulty in achieving the optimal anticoagulant effect, narrow therapeutic window necessitating frequent monitoring of the INR, significant interindividual variability in pharmacological response and numerous drug and food interactions are major limitations to its use [ 5].
Diarrhea may affect electrolyte balance, necessitating close monitoring of serum potassium, magnesium, and calcium, and this may play a role in the higher incidence of high-grade QTc interval prolongation with vandetanib in thyroid versus other tumor types.
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