As a failed RI attempt is a single outcome distinct from the original study, it cannot provide any definitive conclusions necessitating additional studies that the RI approach has neither the ability nor intent of conducting making it a questionable replacement for self-correction.
This hypothesis is further supported by the observation that CK+ CTCs in patients with early stage breast cancer are more heterogeneous with regard to the expression of EMT markers, necessitating additional studies to further elucidate their distinct biological role.
However, results generated from these studies reveal a large list of non-overlapping differentially expressed genes; these discrepancies necessitate additional studies to resolve differences and precisely define the mechanisms by which cigarette smoke exposure impacts gene expression profiles in vitro and in vivo, and to determine whether these changes reflect what is observed in human disease.
Translation into other languages will necessitate additional work using standard protocols for survey translation.
While data from animal models and cell lines have shown an effect of vitamin D on prostate cancer biology [ 3– 8], a direct association between vitamin D levels and prostate cancer risk in humans has not been consistently demonstrated [ 9– 21], necessitating additional high-quality studies.
We excluded HER2-positive cases from this study since their tumours have different biological characteristics, necessitating additional adjuvant treatments.
Second, tendon losses can result from trauma and degenerative diseases, necessitating additional tendon graft material.
These openings may negatively impact the overall capacity of the shear wall, necessitating additional stiffening.
More immunosuppressive drugs helped them adjust, he said, but the donated kidneys may wear out sooner, necessitating additional transplants.
At the same time, proceedings had grown to several thousand pages in length, necessitating additional expense.
In broad agreement with these studies, our results suggest that the anterior frontomedial area may contribute to the detection of implausible or ambiguous interpretations, necessitating additional processing to arrive at a coherent understanding.
