Sentence examples for necessitating a shift from inspiring English sources

Triptrotting had users in 175 countries, but it never grew very large, necessitating a shift in direction.

Unexpectedly, mice that were homozygous null for RAP and transgenic for APPswe/PS1dE9 showed high post-natal mortality, necessitating a shift in focus to examine the levels of amyloid deposition in APPswe/PS1dE9 that were hemizygous null for RAP.

The policy environment as also changed, necessitating a shift in strategy for UNICEF.

This is in part because the introduction of effective therapies has made pure placebo-controlled studies no longer ethical, necessitating a shift to add-on and active-comparator study designs [ 1], which exhibit slower progression and smaller differences between treatment arms, and therefore require longer observation periods and larger numbers of patients to achieve discriminative power.

In contrast, the equivalent Φ5, Φ4, Φ3, and Φ2 residues of the minus NES helix project toward the narrow end of the CRM1 groove, thus necessitating a shift of the entire helix in the opposite direction to allow the hydrophobic side chains to reach the P0, P1, P2, and P3 CRM1 pockets.

would not necessitate a shift in policy.

The advent of big, physical receivers necessitated a shift to more zone defenses from man-to-man coverage.

Navy officials had previously warned that Russian activity in Atlantic waters would necessitate a shift in strategy.

This changing focus has necessitated a shift in structure, toward mobile rapid-reaction forces as opposed to cumbersome, conventional infantry units.

Rapid changes in modern medicine along with advances in the science of learning and memory have necessitated a shift in the way physician knowledge is assessed.

"The altered financial landscape of the university, and of the wider world, necessitates a shift away from rapid development in Allston," Drew Gilpin Faust, Harvard's president, wrote in a letter released Thursday.