Four patients were excluded from further D/F treatment, three because of thrombocytopenia NCI-CTC grade 3 (after the second, fourth and sixth cycle, respectively) and the other patient because of thrombo-cytopenia of NCI-CTC grade 4 (after the eigth cycle of D/F), which was accompanied by anaemia NCI-CTC grade 3, necessitating substitution of platelets and two units of packed red cells.
On the other hand YSZ has certain shortcomings especially its limited temperature capability above 1200 °C which necessitates its substitution in advanced gas turbines.
Many diseases necessitate the substitution of vaginal tissues.
He had intended the structure to convey the possibilities of poured concrete, but a shortage of this material necessitated the substitution of brick covered with cement.
While Gerrard lasted only 33 minutes before being withdrawn with a tight hamstring, and Sturridge sustained a toe injury that necessitated his substitution late on, the head injury sustained by Smalling appeared more serious.
Valdés' clash with Park, however, left him requiring treatment, and although the injury was not sufficient to necessitate a substitution, Valdés chose to leave his next few goal kicks to Piqué.
Due to calcium free dialysate, calcium is eliminated directly as well as indirectly via citrate binding necessitating calcium substitution.
The subsequent ligand substitution, necessitating the displacement of a chelating bipyridine, to arrive at the thermodynamic distribution is much slower.
The susceptibility of the fluorinated isoquinoline core to decomposition, presumably by nucleophilic aromatic substitution, necessitated mild reaction conditions for formation of the B and C rings from 15.
Such discrepancy necessitates urgent clarification because substitution of conventional susceptibility testing with molecular probe based methods such as GeneXpert MTB/RIF (Cepheid, CA, USA) has been strongly advocated but would lead to dramatically different results and treatment regimens (13 ).
However, it is clear that pursuing nurse substitution would necessitate a comprehensive review of both the general practice and nursing workforce [ 31].
