Sentence examples for necessitates significant from inspiring English sources

Discovery of protein biomarkers in clinical samples necessitates significant prefractionation prior to liquid chromatography mass spectrometry (LC MS) analysis.

Likewise, addition of pegylated liposomal doxorubicin (PLD) to frontline carboplatin paclitaxel as a concurrent triplet necessitates significant PLD dose reduction (Bookman, 2003).

These typically contain higher order correlations that distort the filters obtained from spike-triggered analyses, which necessitates significant correction procedures (Theunissen et al. 2001; Felsen et al. 2005; Touryan et al. 2005).

Creating an effective information system to manage such data requires careful database design, and often necessitates significant adaptations to both design and software as new data items and workflows become apparent once the study has started.

The widespread adoption of e-business has necessitated significant financial investments by the affected organizations.

Weak wind resources in the summer necessitate significant non-VRE capacity, which increases capital costs for higher VRE penetrations.

The nature of these concerns, which the FA treats with the utmost seriousness, has necessitated significant further inquiries by the FA and the liaison with external law enforcement agencies.

If the financial burden will eventually become a distraction – generating severe hardship back home or necessitating significant hours at academically unfriendly jobs – it's worth broadening your search.

Mr. Ortega did not pretend that the loss of Mr. Hoberman was some kind of opportunity, saying the continued economic headwinds for newspapers necessitated significant budget cuts.

And much of the fall in asset prices during the Great Recession a decline which necessitated significant deleveraging was a result of tumbling demand rather than the primary cause of it.

A move of just a few miles can necessitate significant adjustments, recent arrivals say, that can be as staggering as grappling with what it means to be the only white face in a particular place for the first time in their lives, or simply adapting to the practice of greeting strangers.