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This bias leads to areas of the genome that are difficult to interrogate with HTS which may require higher coverage, multiple HTS applications or necessitates improvements in HTS technology to be able to be sequenced to a sufficient depth to detect variants.
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Rapid expansion of water-stressed areas necessitates improvement of crops with traits such as drought tolerance and adaptation, through conventional breeding and/or genetic manipulation.
A recent resurgence in basic and applied research on photosynthesis has been driven in part by recognition that fulfilling future food and energy requirements will necessitate improvements in crop carbon-fixation efficiencies.
The broader scope would necessitate improvements in constructing the AIs and strains, output read-outs, data analysis (e.g. automated image analysis using programs such as CalMorph [42] and CellProfiler [43]), and computational modeling.
Because RNAPs pose challenges to available computation technology, these studies may necessitate improvements in methods and hardware applied to very large multiatom systems that include protein and nucleic acid components.
Continuous service evaluations and the monitoring of job satisfaction can be useful to determine various aspects of the services that necessitate improvement.
Acute lymphoblastic leukemia (ALL) is associated with significant morbidity and mortality, necessitating further improvements in diagnosis and therapy.
At present, studies on the motion laws of a pressure-rotating buckling drill string are incomplete, and some are even incorrect, necessitating further improvements.
The cyclic prefix-based orthogonal frequency division multiplexing (CP-OFDM) as the most common and widely used multicarrier technique has many disadvantages in terms of the above mentioned requirements, which necessitates further improvement of the existing multicarrier techniques.
The emergence of mutants of HIV-1 protease resistant to inhibitor action necessitates continuous improvement of existing drugs and also of design of new inhibitors.
This necessitates the improvement of therapeutic techniques to reduce the number of comorbidities presented.
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CEO of Professional Science Editing for Scientists @ prosciediting.com