Sentence examples for necessitates dose from inspiring English sources

Development of toxicity frequently necessitates dose reduction or discontinuation of therapy, despite clinical response.

Chronic neuropathy may be debilitating and often necessitates dose reductions or discontinuation of oxaliplatin.

However, persistence of platelet counts ≤100 × 10/L frequently occurs and generally necessitates dose delays and/or reductions 6.

The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal.

Toxicity did not necessitate dose reductions.

The onset of treatment-related AEs may necessitate dose interruptions, dose adjustments and/or treatment discontinuation in some patients.

These changes could result in suboptimal treatment, particularly for time-dependent antibiotics, and may necessitate dose adjustment.

Pre-existing hepatic disease may alter the metabolic clearance of some antidepressants and may necessitate dose adjustment [ 134].

Additionally, accumulation of biologic changes in host tissue may result in unacceptable toxicities that necessitate dose interruptions or reductions, resulting in decreased dose density and potentially lower efficacy.

The most frequent AEs necessitating dose modifications (occurring in 67% of 500 patients in the regorafenib arm) were dermatological, gastrointestinal, constitutional, metabolic, or laboratory events.

Lamotrigine plasma levels decreased on addition of rifampicin for this patient, necessitating dose increases to maintain plasma levels within the therapeutic range.